Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

In-Plate Chemical Synthesis of Isopeptide-Linked SUMOylated Peptide Fluorescence Polarization Reagents for High-Throughput Screening of SENP Preferences.

Huppelschoten, Yara; Mukhopadhyay, Rishov; Buchardt, Jens; Nielsen, Thomas E; Vertegaal, Alfred C O; Ovaa, Huib; van der Heden van Noort, Gerbrand J.

Chembiochem ; 24(2): e202200601, 2023 01 17.

Artigo em Inglês | MEDLINE | ID: mdl-36377600

2.

Total Chemical Synthesis of a Functionalized GFP Nanobody.

Huppelschoten, Yara; Elhebieshy, Angela F; Hameed, Dharjath S; Sapmaz, Aysegul; Buchardt, Jens; Nielsen, Thomas E; Ovaa, Huib; van der Heden van Noort, Gerbrand J.

Chembiochem ; 23(19): e202200304, 2022 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-35920208

3.

Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors.

Flagstad, Thomas; Pedersen, Mette T; Jakobsen, Tim H; Felding, Jakob; Tolker-Nielsen, Tim; Givskov, Michael; Qvortrup, Katrine; Nielsen, Thomas E.

Bioorg Med Chem Lett ; 57: 128499, 2022 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-34906671

4.

Reactivity and Synthetic Applications of Multicomponent Petasis Reactions.

Wu, Peng; Givskov, Michael; Nielsen, Thomas E.

Chem Rev ; 119(20): 11245-11290, 2019 10 23.

Artigo em Inglês | MEDLINE | ID: mdl-31454230

5.

Disulphide-mediated site-directed modification of proteins.

Nielsen, Thorbjørn; Märcher, Anders; Drobnáková, Zuzana; Hucko, Michal; Stengl, Milan; Balsánek, Vojtech; Wiberg, Charlotte; Nielsen, Per F; Nielsen, Thomas E; Gothelf, Kurt V; Cló, Emiliano.

Org Biomol Chem ; 18(25): 4717-4722, 2020 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-32525502

6.

Interaction Between the a3 Region of Factor VIII and the TIL'E' Domains of the von Willebrand Factor.

Dagil, Lisbeth; Troelsen, Kathrin S; Bolt, Gert; Thim, Lars; Wu, Bo; Zhao, Xin; Tuddenham, Edward G D; Nielsen, Thomas E; Tanner, David A; Faber, Johan H; Breinholt, Jens; Rasmussen, Jakob E; Hansen, D Flemming.

Biophys J ; 117(3): 479-489, 2019 08 06.

Artigo em Inglês | MEDLINE | ID: mdl-31349985

7.

Scaffold Diversity from N-Acyliminium Ions.

Wu, Peng; Nielsen, Thomas E.

Chem Rev ; 117(12): 7811-7856, 2017 Jun 28.

Artigo em Inglês | MEDLINE | ID: mdl-28493667

8.

Peptide-Directed DNA-Templated Protein Labelling for The Assembly of a Pseudo-IgM.

Nielsen, Thorbjørn B; Thomsen, Rasmus P; Mortensen, Michael R; Kjems, Jørgen; Nielsen, Per Franklin; Nielsen, Thomas E; Kodal, Anne Louise B; Cló, Emiliano; Gothelf, Kurt V.

Angew Chem Int Ed Engl ; 58(27): 9068-9072, 2019 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-30995340

9.

Petasis three-component reactions for the synthesis of diverse heterocyclic scaffolds.

Wu, Peng; Nielsen, Thomas E.

Drug Discov Today Technol ; 29: 27-33, 2018 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-30471670

10.

Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents.

Yuan, Mingjun; Chua, Song Lin; Liu, Yang; Drautz-Moses, Daniela I; Yam, Joey Kuok Hoong; Aung, Thet Tun; Beuerman, Roger W; Salido, May Margarette Santillan; Schuster, Stephan C; Tan, Choon-Hong; Givskov, Michael; Yang, Liang; Nielsen, Thomas E.

Beilstein J Org Chem ; 14: 3059-3069, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30591828

11.

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation.

Groizeleau, Julie; Rybtke, Morten; Andersen, Jens Bo; Berthelsen, Jens; Liu, Yang; Yang, Liang; Nielsen, Thomas E; Kaever, Volkhard; Givskov, Michael; Tolker-Nielsen, Tim.

Microbiology (Reading) ; 162(10): 1797-1807, 2016 10.

Artigo em Inglês | MEDLINE | ID: mdl-27526691

12.

A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production.

Wu, Peng; Petersen, Michael Åxman; Cohrt, A Emil; Petersen, Rico; Morgentin, Rémy; Lemoine, Hugues; Roche, Carine; Willaume, Anthony; Clausen, Mads H; Nielsen, Thomas E.

Org Biomol Chem ; 14(29): 6947-50, 2016 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-27356738

13.

In-Bead Screening of Hydroxamic Acids for the Identification of HDAC Inhibitors.

Qvortrup, Katrine; Nielsen, Thomas E.

Angew Chem Int Ed Engl ; 55(14): 4472-5, 2016 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-26945672

14.

Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet-Spengler cyclization/metal-catalyzed cross coupling/amidation sequence.

Petersen, Rico; Cohrt, A Emil; Petersen, Michael Åxman; Wu, Peng; Clausen, Mads H; Nielsen, Thomas E.

Bioorg Med Chem ; 23(11): 2646-9, 2015 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-25703308

15.

Synthesis of 1,4,5 trisubstituted Î³-lactams via a 3-component cascade reaction.

Petersen, Michael Åxman; Mortensen, Michael A; Cohrt, A Emil; Petersen, Rico; Wu, Peng; Fleury-Brégeot, Nicolas; Morgentin, Rémy; Lardy, Claude; Nielsen, Thomas E; Clausen, Mads H.

Bioorg Med Chem ; 23(11): 2695-8, 2015 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-25684425

16.

Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa.

Hansen, Mette R; Jakobsen, Tim H; Bang, Claus G; Cohrt, Anders Emil; Hansen, Casper L; Clausen, Janie W; Le Quement, Sebastian T; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas E.

Bioorg Med Chem ; 23(7): 1638-50, 2015 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-25716005

17.

A Four-Component Reaction for the Synthesis of Dioxadiazaborocines.

Flagstad, Thomas; Petersen, Mette T; Nielsen, Thomas E.

Angew Chem Int Ed Engl ; 54(29): 8395-7, 2015 Jul 13.

Artigo em Inglês | MEDLINE | ID: mdl-26068978

18.

Comparative systems biology analysis to study the mode of action of the isothiocyanate compound Iberin on Pseudomonas aeruginosa.

Tan, Sean Yang-Yi; Liu, Yang; Chua, Song Lin; Vejborg, Rebecca Munk; Jakobsen, Tim Holm; Chew, Su Chuen; Li, Yingying; Nielsen, Thomas E; Tolker-Nielsen, Tim; Yang, Liang; Givskov, Michael.

Antimicrob Agents Chemother ; 58(11): 6648-59, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25155599

19.

Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators.

Hansen, Mette R; Le Quement, Sebastian T; Jakobsen, Tim H; Skovstrup, Søren; Taboureau, Olivier; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas E.

Chembiochem ; 15(3): 460-5, 2014 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-24436223

20.

Synthesis of heterocycles through transition-metal-catalyzed isomerization reactions.

Ishoey, Mette; Nielsen, Thomas E.

Chemistry ; 20(29): 8832-40, 2014 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-24924616

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